Monday, May 5, 2008

Biological Immortality

Biological immortality can be defined as the absence of a sustained increase in rate of mortality as a function of chronological age. A cell or organism that does not experience, or at some future point will cease aging, is biologically immortal. However this definition of immortality was challenged in the new "Handbook of the Biology of Aging", because the increase in rate of mortality as a function of chronological age may be negligible at extremely old ages (late-life mortality plateau). But even though the rate of mortality ceases to increase in old age, those rates are very high (e.g., 50% chance of surviving another year at age 110 or 115 years of age).
There is no known organism or individual cell that is inviolably immortal. Any life enjoying biological immortality can die if exposed to a toxic environment, or otherwise killed or destroyed

Telomere


A telomere is a region of repetitive DNA at the end of chromosomes, which protects the end of the chromosome from destruction. Derived from the Greek telos (end) and meres (part).
During cell division, the enzymes that duplicate the chromosome and its DNA can't continue their duplication all the way to the end of the chromosome. If cells divided without telomeres, they would lose the end of their chromosomes, and the necessary information it contains. (In 1972, James Watson named this phenomenon the "end replication problem.") The telomere is a disposable buffer, which is consumed during cell division and is replenished by an enzyme, the telomerase reverse transcriptase.
This mechanism usually limits cells to a fixed number of divisions, and animal studies suggest that this is responsible for aging on the cellular level and affects lifespan. Telomeres protect a cell's chromosomes from fusing with each other or rearranging. These chromosome abnormalities can lead to cancer, so cells are normally destroyed when telomeres are consumed. Most cancer is the result of cells bypassing this destruction. Biologists speculate that this mechanism is a tradeoff between aging and cancer.

Chondrocyte

Chondrocytes (from Greek chondros cartilage + kytos cell) are the only cells found in cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans. Although chondroblast is still commonly used to describe an immature chondrocyte, use of the term is discouraged, for it is technically inaccurate since the progenitor of chondrocytes (which are mesenchymal stem cells) can also differentiate into osteoblasts.

Fibroblast


A fibroblast is a type of cell that synthesizes and maintains the extracellular matrix of many animal tissues. Fibroblasts provide a structural framework (stroma) for many tissues, and play a critical role in wound healing. They are the most common cells of connective tissue in animals. Fibroblasts were first discovered by Dr. Matthias De Oliveira in 1968.
The main function of fibroblasts is to maintain the structural integrity of connective tissues by continuously secreting precursors of the extracellular matrix. Fibroblasts secrete the precursors of all the components of the extracellular matrix, primarily the ground substance and a variety of fibres. The composition of the extracellular matrix determines the physical properties of connective tissues.
Fibroblasts are morphologically heterogeneous with diverse appearances depending on their location and activity. Though morphologically inconspicuous, ectopically transplanted fibroblasts can often retain positional memory of the location and tissue context where they had previously resided, at least over a few generations